Repurposing an Old Drug for a New Epidemic: Ursodeoxycholic Acid to Prevent Recurrent Clostridioides difficile Infection.
Clin Infect Dis. 2018 Jul 18;:
Authors: Webb BJ, Brunner A, Lewis J, Ford CD, Lopansri B
Recurrent Clostridioides difficile infection (rCDI) may be mediated in part by secondary bile acids. Here we report salvage therapy with ursodeoxycholic acid (UDCA) to prevent rCDI in 16 high-risk patients. Patients on UDCA had a low observed recurrence rate (12.5%). Controlled trials are needed to confirm these observations.
PMID: 30020421 [PubMed - as supplied by publisher]