Opioid-Induced Adrenal Insufficiency.

Link to article at PubMed

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Opioid-Induced Adrenal Insufficiency.

Mayo Clin Proc. 2018 Jul;93(7):937-944

Authors: Donegan D, Bancos I

One in 10 Americans experience chronic pain. Although opioids do play a role in the management of pain, long-term opioid use may lead to adverse effects. Endocrine-related adverse effects have been described but remain poorly recognized. Opioid-induced adrenal insufficiency occurs because of suppression of hypothalamic-pituitary-adrenal communication and may be challenging to diagnose but has been reported in 9% to 29% of patients receiving long-term opiate therapy. Little data exist to guide case detection and patient management. Treatment includes cessation of opiates (the inciting factor) if possible and glucocorticoid replacement.

PMID: 29976376 [PubMed - in process]

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