Type and doses of oral anticoagulants and adherence to anticoagulant treatment in elderly patients with atrial fibrillation: the ESPARTA study.

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Type and doses of oral anticoagulants and adherence to anticoagulant treatment in elderly patients with atrial fibrillation: the ESPARTA study.

J Comp Eff Res. 2018 Mar;7(3):223-232

Authors: Mostaza JM, Suárez Fernández C, Castilla Guerra L, Suriñach JM, Tamarit JJ, Diaz Diaz JL, García Polo I, Santamaria EF, Fidalgo Fernández MA, de la Guerra Acebal C, Dávila Ramos MF, Ràfols C

Abstract
AIM: To analyze the use of oral anticoagulants in elderly patients with atrial fibrillation in clinical practice.
PATIENTS & METHODS: Cross-sectional and multicenter study performed in atrial fibrillation patients ≥75 years treated with oral anticoagulants ≥3 months.
RESULTS: 837 patients (83.0 ± 5.0 years; CHA2DS2-VASc 5.0 ± 1.4; HAS-BLED 2.1 ± 0.9; 70.8% vitamin K antagonists; 29.2% direct oral anticoagulants [DOACs]) were included. Poor adherence was observed in 27.9% of patients. Higher scores in the Pfeiffer's test and FRAIL scale were associated with poorer adherence. Among patients treated with DOACs, 62.3% received the lower doses. Having high CHADS2 score and being older were associated with the use of low doses.
CONCLUSION: 28% of patients had a poor adherence to anticoagulant treatment. 62% of patients were treated with the lower doses of DOACs.

PMID: 29465254 [PubMed - in process]

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