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Risk stratification for the development of venous thromboembolism in hospitalized patients with cancer.
J Thromb Haemost. 2018 May 07;:
Authors: Parker A, Peterson E, Lee AYY, de Wit C, Carrier M, Polley G, Tien J, Wu C
Abstract
INTRODUCTION: The Khorana score is a validated risk assessment score for estimating the risk of symptomatic venous thromboembolism (VTE) in outpatients with cancer. The objective of this study was to assess the Khorana score for predicting the development of VTE in cancer patients during hospital admission.
METHODS: We conducted an analysis of consecutive, adult cancer patients hospitalized for medical reasons between January and June 2010 in 3 academic medical centers. Information on objectively diagnosed, symptomatic VTE during hospitalization, use of anticoagulant thromboprophylaxis (TP), and Khorana score variables at the time of admission were collected.
RESULTS: A total of 1398 patients were included. Mean age was 62 years, 51.2% were male, and mean BMI was 25.9 kg/m2. The most frequent reasons for hospitalization were chemotherapy administration (22.3%) followed by pain control and palliation (21.4%). The overall incidence of VTE was 2.9% (95% CI 2.0-3.8%), occurring in 5.4% (95% CI 1.9-8.9%), of the high-, 3.2% (95%CI 2.0-4.4%), of the intermediate-, and 1.4% (95% CI 0.3-2.6%), of the low-risk groups. High-risk patients were more likely than low-risk patients to have VTE (OR 3.9, 95% CI 1.4-11.2).
CONCLUSION: The Khorana score is predictive of in-hospital, symptomatic VTE development in cancer patients who are hospitalized for medical reasons and may be a useful tool for tailoring inpatient anticoagulant thromboprophylaxis. This article is protected by copyright. All rights reserved.
PMID: 29733498 [PubMed - as supplied by publisher]