Biomarkers of Sepsis and Bloodstream Infections: The Role of Procalcitonin and Proadrenomedullin with Emphasis in Patients with Cancer.

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Biomarkers of Sepsis and Bloodstream Infections: The Role of Procalcitonin and Proadrenomedullin with Emphasis in Patients with Cancer.

Clin Infect Dis. 2018 Apr 16;:

Authors: El Haddad H, Chaftari AM, Hachem R, Chaftari P, Raad II

Abstract
Sepsis and bloodstream infections remain a leading cause of death in immunocompromised cancer patients. The management of these serious infections consist of empiric use of antimicrobial agents which are often overused. Procalcitonin and proadrenomedullin are biomarkers that have been extensively evaluated in the general populations with little emphasis in the immunocompromised cancer patient population where they may have promising roles in the management of febrile patients. In this review, we summarize the available evidence of the potential role of these available biomarkers in guiding antimicrobial therapy to optimize resource utilization in the general patient population. Special emphasis is given to the role of these two biomarkers in the immunocompromised and critically ill cancer patients highlighting the distinctive utility of each.

PMID: 29668936 [PubMed - as supplied by publisher]

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