Acute chest syndrome in sickle cell disease.

Link to article at PubMed

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Acute chest syndrome in sickle cell disease.

Hosp Pract (1995). 2018 Apr 12;:

Authors: Farooq S, Abu Omar M, Salzman GA

Acute chest syndrome (ACS) is a leading complication of sickle cell disease (SCD) with significant morbidity and mortality. ACS is the most common cause of death and the second most common cause of hospitalization in patients with SCD. Delineating the specific cause of ACS is often difficult, and multiple risk factors that precipitate ACS frequently coexist. The prominent risk factors include infection, hypoxia, bronchial hyperresponsiveness, the SCD genotype, and opioid use. The key to the successful treatment of ACS is early recognition and initiation of treatment without delay. The main goal is to prevent and treat acute respiratory failure and, thus, minimize irreversible lung damage. This review focuses on the risk factors, pathogenesis, clinical presentation, and management of ACS.

PMID: 29648482 [PubMed - as supplied by publisher]

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