Levorphanol for Treatment of Intractable Neuropathic Pain in Cancer Patients.

Link to article at PubMed

Levorphanol for Treatment of Intractable Neuropathic Pain in Cancer Patients.

J Palliat Med. 2018 Jan 29;:

Authors: Reddy A, Ng A, Mallipeddi T, Bruera E

Abstract
Neuropathic pain in cancer patients is often difficult to treat, requiring a combination of several different pharmacological therapies. We describe two patients with complex neuropathic pain syndromes in the form of phantom limb pain and Brown-Sequard syndrome who did not respond to conventional treatments but responded dramatically to the addition of levorphanol. Levorphanol is a synthetic strong opioid that is a potent N-methyl-d-aspartate receptor antagonist, mu, kappa, and delta opioid receptor agonist, and reuptake inhibitor of serotonin and norepinephrine. It bypasses hepatic first-pass metabolism and thereby not subjected to numerous drug interactions. Levorphanol's unique profile makes it a potentially attractive opioid in cancer pain management.

PMID: 29377758 [PubMed - as supplied by publisher]

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