Elevated Serum Midkine in Patients With Acute Pancreatitis.

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Elevated Serum Midkine in Patients With Acute Pancreatitis.

Am J Med Sci. 2017 Dec;354(6):548-552

Authors: Li Y, Lu Y, Shen J, Xu C

Abstract
BACKGROUND: Midkine (MK) is reported to be involved in the pathogenesis of numerous pathologies, but the expression of MK in acute pancreatitis (AP) has not been well studied and documented.
METHODS: In this study, the temporal changes of serum MK were assessed in 97 patients with AP by enzyme-linked immunosorbent assay.
RESULTS: The concentration of serum MK increased along with the severity of AP. Serum MK level increased more significantly in patients with organ failure than in those without organ failure. A more obvious elevation of serum MK level was also observed in patients with pancreatic necrosis.
CONCLUSION: Serum MK might be a useful marker in the clinical diagnosis of AP.

PMID: 29208250 [PubMed - in process]

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