Cytokine responses, microbial etiology and short-term outcome in community-acquired pneumonia.
Eur J Clin Invest. 2017 Nov 24;:
Authors: Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Aukrust P, Mollnes TE, Heggelund L
BACKGROUND: The inflammatory response in community-acquired pneumonia (CAP) is orchestrated through activation of cytokine networks and the complement system. We examined the association of multiple cytokines and the terminal complement complex (TCC) with microbial etiology, disease severity and short-term outcome.
MATERIALS AND METHODS: Plasma levels of 27 cytokines and TCC were analyzed in blood samples obtained at hospital admission, clinical stabilization and 6-weeks follow up from 247 hospitalized adults with CAP. Fourteen mediators were included in final analyses. Adverse short-term outcome was defined as intensive care unit (ICU) admission and 30-day mortality.
RESULTS: Cytokine and TCC levels were dynamic in the clinical course of CAP, with highest levels seen at admission for most mediators. Admission levels of cytokines and TCC did not differ between groups of microbial etiology. High admission levels of IL-6 (odds ratio (OR) 1.47, 95% confidence interval (CI) 1.18 - 1.84, p=0.001), IL-8 (OR 1.79, 95% CI 1.26 - 2.55, p=0.001) and MIP-1β (OR 2.28, 95% CI 1.36 - 3.81, p=0.002) were associated with a CURB-65 severity score of ≥3, while IL-6 (OR 1.37, 95% CI 1.07 - 1.74, p=0.011) and MIP-1β (OR 1.86, 95% CI 1.03 - 3.36, p=0.040) were associated with a high risk of an adverse short-term outcome.
CONCLUSIONS: In this CAP cohort, admission levels of IL-6, IL-8 and MIP-1β were associated with disease severity and/or adverse short-term outcome. Still, for most mediators, only non-significant variations in inflammatory responses were observed for groups of microbial etiology, disease severity and short-term outcome. This article is protected by copyright. All rights reserved.
PMID: 29171871 [PubMed - as supplied by publisher]