Clinical Perspectives in the Diagnosis and Management of Histoplasmosis.

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Clinical Perspectives in the Diagnosis and Management of Histoplasmosis.

Clin Chest Med. 2017 Sep;38(3):403-415

Authors: Azar MM, Hage CA

Abstract
With increasing numbers of travelers and immunocompromised patients, histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, has become a disease of national extent. The clinical spectrum of histoplasmosis is very wide, in terms of disease cadence, onset, distribution, and severity. A multipronged approach is recommended for diagnosis. Manifestations that are always treated include moderate to severe acute pulmonary histoplasmosis, disseminated disease, and histoplasmosis in immunocompromised individuals. Amphotericin B is the drug of choice for moderate to severe and disseminated presentations, whereas itraconazole is appropriate for mild disease and as step-down therapy.

PMID: 28797485 [PubMed - in process]

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