Serum sodium correction rate and the outcome in severe hyponatremia.
Am J Emerg Med. 2017 Nov;35(11):1691-1694
Authors: Giordano M, Ciarambino T, Priore EL, Castellino P, Malatino L, Cataliotti A, Paolisso G, Adinolfi LE
STUDY OBJECTIVE: We investigated the serum sodium correction rate on length of hospitalization and survival rate, in severe chronic hyponatremic patients at the Emergency Department (ED).
DESIGN: An observational study using clinical chart review.
SETTING: The ED of the University Hospital of Marcianise, Caserta, Italy with approximately 30,000 patients visits a year.
TYPE OF PARTICIPANTS: We reviewed sixty-seven patients with severe hyponatremia subdivided in 2 subgroups: group A consisting of 35 patients with serum sodium correction rate<0.3mmol/h and group B consisting of 32 patients with serum sodium correction rate between <0.5 and ≥0.3mmol/h.
INTERVENTION: Emergency patients were evaluated for serum sodium correction rate for hyponatremia by clinical chart review.
MEASUREMENTS AND MAIN RESULTS: Severe hyponatremia was defined as a serum sodium level<120mmol/l. Mean serum sodium correction rate of hyponatremia was of 0.17±0.09% in group A and 0.41±0.05% in group B (p<0.001 vs group A). The length of hospital stay was 10.7±3.7days for group A, and it was significantly decreased to 3.8±0.4days for group B (p<0.005 vs group A). In addition we observed that correction rate of hyponatremia in group A was associated with a significantly lower survival rate (25%) in comparison to group B (60%) (p<0.001 vs group A).
CONCLUSION: We observed that serum sodium correction rate ≥0.3 and <0.5mmol/h was associated with a shorter length of hospital stay and a major survival rate.
PMID: 28600073 [PubMed - indexed for MEDLINE]