Acute Ischemic Stroke Intervention.

Link to article at PubMed

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Acute Ischemic Stroke Intervention.

J Am Coll Cardiol. 2016 Jun 7;67(22):2631-44

Authors: Khandelwal P, Yavagal DR, Sacco RL

Abstract
Acute ischemic stroke (AIS) is the leading cause of disability worldwide and among the leading causes of mortality. Although intravenous tissue plasminogen activator (IV-rtPA) was approved nearly 2 decades ago for treatment of AIS, only a minority of patients receive it due to a narrow time window for administration and several contraindications to its use. Endovascular approaches to recanalization in AIS developed in the 1980s, and recently, 5 major randomized trials showed an overwhelming superior benefit of combining endovascular mechanical thrombectomy with IV-rtPA over IV-rtPA alone. In this paper, we discuss the evolution of catheter-based treatment from first-generation thrombectomy devices to the game-changing stent retrievers, results from recent trials, and the evolving stroke systems of care to provide timely access to acute stroke intervention to patients in the United States.

PMID: 27256835 [PubMed - in process]

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