Efficacy of non-vitamin K antagonist oral anticoagulants for Lemierre syndrome.
Am J Emerg Med. 2016 Mar 18;
Authors: Kubota M, Daidoji H, Takaya N, Tokunaga K, Sonoo T, Nakamura K
The use of anticoagulants for patients with Lemierre syndrome, which consists of pharyngeal infection-related thrombophlebitis of the internal jugular vein and septic embolism, is controversial. In this study, we report a 65-year-old woman with Lemierre syndrome in whom anticoagulant therapy was effective for thrombotic occlusion involving the sigmoid sinus. She consulted our hospital with pharyngeal pain and dyspnea. Contrast-enhanced cervical computed tomography revealed thrombus formation involving the right internal jugular vein to sigmoid sinus. A blood culture test showed a positive reaction to Streptococcus pyogenes. Under a diagnosis of Lemierre syndrome, edoxaban, an anticoagulant (non-vitamin K antagonist oral anticoagulant) was administered in addition to an antibiotic, leading to an improvement. The present case suggests that non-vitamin K antagonist oral anticoagulant is useful as an anticoagulant for infectious thrombophlebitis, including Lemierre syndrome, and septic embolism, other than warfarin, which has been routinely used.
PMID: 27079502 [PubMed - as supplied by publisher]