Efficacy of Lantibiotic Treatment of Staphylococcus aureus-induced Skin Infections, Monitored by in vivo Bioluminescent Imaging.
Antimicrob Agents Chemother. 2016 Apr 11;
Authors: van Staden AD, Heunis T, Smith C, Deane S, Dicks LM
Staphylococcus aureusis a bacterial pathogen responsible for the majority of skin and soft tissue infections. Antibiotics are losing their efficacy as treatment for skin and soft tissue infections as a result of increased resistance in a variety of pathogens, includingS. aureus It is thus imperative to explore alternative antimicrobial treatments to ensure future treatment options for skin and soft tissue infections. A select few lantibiotics, a group of natural defence peptides produced by bacteria, inhibit the growth of numerous clinicalS. aureusisolates, including methicillin-resistant strains. In this study, the antimicrobial activity of nisin, clausin and amyloliquecidin, separately administered, was compared to a mupirocin-based ointment, which is commonly used as treatment forS. aureus-induced skin infections. Full thickness excisional wounds, generated on the dorsal surface of mice, were infected with a bioluminescent strain ofS. aureus(strain Xen 36). Infections were monitored in real time usingin vivobioluminescent imaging. Lantibiotic treatments significantly reduced the bioluminescence ofS. aureusXen 36, similar to that recorded with mupirocin treatment. Wound closure was, however, more pronounced during lantibiotic treatment. Lantibiotics thus have the potential to be used as an alternative treatment option forS. aureus-induced skin infections.
PMID: 27067340 [PubMed - as supplied by publisher]