Why is antibiotic resistance a deadly emerging disease?
Clin Microbiol Infect. 2016 Jan 21;
Authors: Courvalin P
Abstract
Evolution of bacteria towards resistance to antimicrobial agents, including multidrug resistance, is unavoidable because it represents a particular aspect of the general evolution of bacteria that is unstoppable. Therefore, the only means of dealing with this situation is to delay the emergence and subsequent dissemination of resistant bacteria or resistance genes. In this review, we will consider the biochemical mechanisms and the genetics bacteria use to offset antibiotic selective pressure. The data provided are mainly, if not exclusively, taken from the work carried out in the laboratory, although there are numerous other examples in the literature.
PMID: 26806259 [PubMed - as supplied by publisher]