Clinical relevance of rhinovirus infections among adult hospitalized patients.
Braz J Infect Dis. 2015 Mar-Apr;19(2):118-24
Authors: Fica A, Dabanch J, Andrade W, Bustos P, Carvajal I, Ceroni C, Triantafilo V, Castro M, Fasce R
UNLABELLED: Human rhinovirus (HRV) is an emerging viral pathogen.
AIM: To characterize a group of patients admitted due to infection by this agent in a general hospital in Chile.
METHODS: Cases were identified by RT-PCR for 1 year through active surveillance of patients admitted with severe respiratory illness. Diagnosis was not available during hospitalization. Thirty-two cases were identified, 90% were ≥60 years old or had co-morbid conditions. Human rhinovirus-related admissions represented 23.7% of hospitalization due to severe acute respiratory infections among adults and ranked second to influenza (37.8%). Patients presented with pneumonia (68.8%), decompensated chronic lung conditions (21.9%), heart failure or influenza-like illness (6.3% each). Admission to intensive or intermediate care units was required by 31.2% and in-hospital mortality reached 12.5%. A CURB-65 score ≥3 was significantly associated to in-hospital mortality (p<0.05). Most patients received antibiotics (90%).
CONCLUSIONS: Human rhinovirus infections in elderly patients with co-morbid conditions are associated with hospitalizations, requiring critical or semi-critical antibiotics use. A high CURB-65 score was associated to in-hospital mortality.
PMID: 25523079 [PubMed - indexed for MEDLINE]