Comparative in vitro activity of oral antimicrobial agents against Enterobacteriaceae from patients with community-acquired urinary tract infections in three European countries.
Clin Microbiol Infect. 2015 Aug 27;
Authors: Kresken M, Körber-Irrgang B, Biedenbach DJ, Batista N, Besard V, Cantón R, García-Castillo M, Kalka-Moll W, Pascual A, Schwarz R, Van Meensel B, Wisplinghoff H, Seifert H
Abstract
Enterobacteriaceae causing community-acquired urinary tract infections (CA-UTI) were examined in selected outpatient clinics and hospitals in Belgium, Germany, and Spain using EUCAST breakpoints for susceptibility. A total of 1,190 isolates were collected. Escherichia coli isolates were resistant to amoxicillin-clavulanic acid (28.1%), ciprofloxacin (23.4%), and trimethoprim-sulfamethoxazole (21.4%) compared to fosfomycin and nitrofurantoin (each, <1.5%). Ceftibuten and ceftriaxone activity (MIC50/90 ≤0.25/0.5 mg/L) was comparable. Ceftibuten (MIC90, ≤0.25 mg/L) was also active against Proteus mirabilis and Klebsiella spp. ESBL phenotypes were 7.1% for E. coli, Klebsiella pneumoniae (5.6%), and P. mirabilis (0.4%). Resistance was common among men and elderly women.
PMID: 26321667 [PubMed - as supplied by publisher]