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Factors influencing mortality in solid organ transplant recipients with bloodstream infection.
Clin Microbiol Infect. 2015 Aug 4;
Authors: Oriol I, Sabé N, Melilli E, Lladó L, González-Costello J, Soldevila L, Carratalà J
Abstract
Although bloodstream infection (BSI) is a major cause of mortality after solid organ transplantation, information regarding its prognostic factors is scarce. To identify risk factors for 30-day mortality in solid organ transplant recipients with bloodstream infection, we prospectively recorded all episodes of BSI occurring in adult SOT recipients from January 2007 to October 2014 at a university hospital. We identified 361 consecutive episodes of BSI involving 246 patients. The 30-day case-fatality rate from the onset of BSI was 11.4%. Factors independently associated with 30-day mortality using a logistic regression analysis were shock at presentation (OR, 13.658; 95% CI, 5.985-31.168), acute graft rejection in the previous six months (OR, 3.681; 95% CI, 1.059-12.795) and platelet count <50,000x10(9)/L (OR, 3.070; 95% CI, 1.173-8.038). Kidney recipients were the patients with the best prognosis (OR, 0.375; 95% CI, 0.156-0.900). Our findings may help to identify SOT recipients with BSI who are at the highest risk of death.
PMID: 26253289 [PubMed - as supplied by publisher]