Predictors of Candida spp. as causative agents of catheter-related bloodstream infections.

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Predictors of Candida spp. as causative agents of catheter-related bloodstream infections.

Diagn Microbiol Infect Dis. 2014 Nov;80(3):200-3

Authors: Nagao M, Hotta G, Yamamoto M, Matsumura Y, Ito Y, Takakura S, Ichiyama S

Abstract
We conducted this study to identify risk factors that may predict whether Candida spp. are causative agents of suspected catheter-related bloodstream infections (CRBSIs). All patients with laboratory-confirmed CRBSIs at Kyoto University Hospital between 2009 and 2011 were included. We compared the clinical features of candidal CRBSIs (78 cases) and non-candidal CRBSIs (258 cases). According to a multivariate analysis, a solid tumor (odds ratio [OR], 3.11; 95% confidence interval [CI], 1.75-5.53), total parental nutrition (OR, 2.65; 95% CI, 1.39-5.06), and the administration of anti-anaerobic agents (OR, 2.22; 95% CI, 1.03-4.79) were significantly more common among candidal CRBSIs. The (1,3)-β-D-glucan (BDG) test was positive among 94.6% (35/37) of candidal CRBSI patients and 9.4% (10/106) of non-candidal CRBSI cases. The administration of antifungal agents may be considered for patients with these risk factors, especially when the BDG test is positive.

PMID: 25266673 [PubMed - indexed for MEDLINE]

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