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New Oral Anticoagulants: Their Role in Stroke Prevention in High-Risk Patients with Atrial Fibrillation.
Med Clin North Am. 2015 Jul;99(4):759-780
Authors: Ferns SJ, Naccarelli GV
Abstract
Based on efficacy, safety, and ease of use, novel oral anticoagulants will likely replace VKAs for many if not most patients with atrial fibrillation. Novel anticoagulants have a lower rate of intracranial hemorrhage compared with vitamin K antagonists. The incidence of other life-threatening bleeds is similar if not lower. Dose adjustments need to be made based on renal function and advanced age. There is at present a need for an antidote for these new drugs.
PMID: 26042881 [PubMed - as supplied by publisher]