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Influence of the previous use of β-blockers on the early clinical course of acute coronary syndromes.
Intern Emerg Med. 2015 May 20;
Authors: Garcia-Rubira JC, Almendro-Delia M, Calvo-Taracido M, Blanco-Ponce E, Bastos-Amador P, Reina-Toral A, Calvo-Jambrina R, Cruz-Fernández JM, Garcia-Alcántara A, Hidalgo-Urbano R
Abstract
Recent studies have recently questioned the current role of β-blockers in myocardial infarction. Our purpose is to analyze the influence of the previous use of β-blockers on the early course of patients admitted because of acute coronary syndrome (ACS). We analyzed the data of 37.359 patients included in the ARIAM-Andalucia Registry. Of them, 7759 (20.8 %) were previously receiving β-blockers. BB patients were older, more often female, had more risk factors and vascular disease, and less often had an ST-elevation myocardial infarction. In the unadjusted analysis, BB patients less often had ventricular fibrillation or atrioventricular block, and more often a Killip classification >1, and no difference of in-hospital mortality (5.7 vs 5.6 %). After logistic regression analysis and propensity score matching, no differences in complications or mortality (odds ratio 0.997, 95 % confidence interval 0.882-1.128) were found in relationship to previous β-blockers. In conclusion, we find that the previous administration of β-blockers is not an independent predictor of the early prognosis of ACS.
PMID: 25990485 [PubMed - as supplied by publisher]