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Antibiotics for Abdominal Sepsis.
N Engl J Med. 2015 May 21;372(21):2062-2063
Authors: Wenzel RP, Edmond MB
Abstract
Major milestones in surgery have included safe sutures to promote tissue integrity, cautery to minimize bleeding, the use of anesthesia to avoid pain, and antisepsis to prevent operative contamination. In the antibiotic era, surgical procedures for source control in abdominal sepsis have been complemented with drugs targeting persistent organisms after luminal inflammation, obstruction, or perforation. The appropriate duration of postsurgical antibiotic therapy has been unclear.(1) However, if safe, shorter courses would be desirable to minimize drug-related adverse events, the selection of antibiotic resistance, and costs. In this issue of the Journal, Sawyer and colleagues(2) present data from the Study . . .
PMID: 25992751 [PubMed - as supplied by publisher]