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The Clinical Epidemiology and Malignancies Associated with Streptococcus bovis Biotypes in 506 Cases of Bloodstream Infections.
J Infect. 2015 May 14;
Authors: Corredoira J, Grau I, Garcia-Rodriguez JF, Alonso-Garcia P, Garcia-Pais MJ, Rabuñal R, Garcia-Garrote F, Ardanuy C, Coira A, Lopez-Alvarez MJ, Pallares R
Abstract
OBJECTIVES: To determine the incidence of Streptococcus bovis (Sb) biotypes causing bacteraemia and associated malignancies.
METHODS: This is a retrospective analysis of patients with Sb bacteraemia, pulled out from a prospective surveillance protocol of bacteraemia cases, in three areas of Spain (1990-2013): a cattle area (Lugo), a fishing area (Ferrol) and an urban area (Barcelona). Colonoscopy and Sb biotypes (Sb-I and Sb-II) were determined in most cases.
RESULTS: 506 patients with Sb bacteraemia; mean age 68.1(+/-14.1) years, and 66.2% were males. The cattle area, compared with the fishing and urban areas, had higher incidence of bacteraemia by Sb-I (40.29 vs 9.38 vs 6.15 cases/10(6) person-years, P<.001) and bacteraemia by Sb-II (29.07 vs 9.84 vs 13.37 cases/10(6) person-years, P<.001). The Sb-I cases (N=224), compared with Sb-II cases (n=270), had greater rates of endocarditis (77.6% vs 9.6%, P<.001) and colorectal neoplasm (CRN) (50.9% vs 16.6%, P<.001), and smaller rates of biliary tract infection (2.2% vs 29.6%, P<.001) and non-colorectal malignancy (8.9% vs 31.4%, P<.001).
CONCLUSION: There was a link between the cattle area and higher incidence of Sb bacteraemia. Sb-I differed from Sb-II cases in clinical findings and associated malignancies. Colonoscopy is mandatory in cases of endocarditis or bacteraemia caused by Sb-I.
PMID: 25982024 [PubMed - as supplied by publisher]