| Related Articles |
Relation between admission serum potassium levels and long-term mortality in acute coronary syndrome.
Intern Emerg Med. 2015 May 19;
Authors: Peng Y, Huang FY, Liu W, Zhang C, Zhao ZG, Huang BT, Liao YB, Li Q, Chai H, Luo XL, Ren X, Chen C, Meng QT, Huang J, Wang H, Chen M
Abstract
Serum potassium homeostasis play an important role in myocardial function, but the impact of serum potassium levels on long-term mortality has not been well evaluated. In the current study, we investigated patients with acute coronary syndrome (ACS) and analyzed the relationship between admission serum potassium levels and long-term mortality. Between July 2008 and September 2012, 2369 patients with ACS that was confirmed by coronary angiography were enrolled in this study and completed the follow-up. The serum potassium level was evaluated within first 24 h after admission. The primary outcome in this study was all-cause mortality. Patients were categorized into five groups to determine the relation between admission serum potassium levels and long-term mortality: <3.5, 3.5 to <4.0, 4.0 to <4.5, 4.5 to <5.0, and >5 mEq/L. There was a U-shaped relationship between admission serum potassium levels and long-term mortality that persisted after multivariable adjustment. The mortality risk was lowest in the group of patients with potassium levels of 3.5 to <4.0 mEq/L, whereas mortality was higher in patients with potassium levels >4.5 [hazard ratio (HR) 1.62, 95 % confidence interval (CI) 0.90 to 2.93 and HR 1.55, 95 % CI 0.54 to 4.49, for patients with potassium levels of 4.5 to <5.0 mEq/L and ≥5.0 mEq/L, respectively] or <3.5 mEq/L (HR 2.14, 95 % CI 1.28 to 3.59). There was a U-shaped relationship between admission serum potassium levels and long-term mortality for ACS patients; in particular, among the examined patients, the lowest mortality was observed in those with admission serum potassium levels of between 3.5 and <4.5 mEq/L compared with those who had higher or lower potassium levels.
PMID: 25986480 [PubMed - as supplied by publisher]