Alogliptin: A Review of Its Use in Patients with Type 2 Diabetes Mellitus.
Drugs. 2015 Apr 9;
Authors: Keating GM
The dipeptidyl peptidase-4 inhibitor alogliptin (Nesina(®), Vipidia(®)) is approved in numerous countries worldwide for the treatment of type 2 diabetes mellitus. Fixed-dose combinations of alogliptin/metformin (Kazano(®), Vipdomet(®)) and alogliptin/pioglitazone (Oseni(®), Incresync(®)) are also available. This article reviews the clinical efficacy and tolerability of oral alogliptin in the treatment of type 2 diabetes. Results of randomized controlled trials demonstrated that oral alogliptin improved glycaemic control when administered as monotherapy, as dual therapy in combination with metformin, pioglitazone, a sulfonylurea, voglibose or insulin, or as triple therapy in combination with metformin plus pioglitazone. Alogliptin was generally well tolerated in patients with type 2 diabetes and was weight neutral, with a low risk of hypoglycaemia. Results of the large, well designed EXAMINE trial revealed that alogliptin was not associated with an increased risk of major cardiovascular events in patients with type 2 diabetes and recent acute coronary syndrome. In conclusion, alogliptin is a useful option for the treatment of patients with type 2 diabetes.
PMID: 25855222 [PubMed - as supplied by publisher]