Angiotensin-converting enzyme (ACE) inhibitor angioedema requiring admission to an intensive care unit.
Am J Med. 2015 Mar 10;
Authors: Soo Hoo GW, Lin HK, Junaid I, Klaustermeyer WB
Abstract
OBJECTIVE: To review consecutive cases of angiotensin converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit (ICU) .
PATIENTS AND METHODS: Fifty subjects with ACE inhibitor angioedema admitted from 1998-2011 were reviewed.
RESULTS: All 50 subjects were men, 62.8 + 8.4 years of age, 76% African-Americans. Fifteen (30%) required ventilatory support and 2 (4%) required tracheostomy. Over half (56%) had taken ACE-inhibitors for over a year. Logistic regression identified dyspnea and tongue involvement with the need for ventilatory support. (p < 0.01). Hypercapnia (PaCO2 = 45.2 + 6.7; p = 0.046) also identified patients needing ventilatory support.
CONCULUSIONS: Ventilatory support was provided for about one third of those with ACE-inhibitor associated angioedema. Angioedema can occur even after extended use. Dyspnea and tongue involvement identified patients requiring ventilatory support.
PMID: 25770035 [PubMed - as supplied by publisher]