Subtleties in practical application of prolonged infusion of β-lactam antibiotics.
Int J Antimicrob Agents. 2015 Feb 16;
Authors: De Waele JJ, Lipman J, Carlier M, Roberts JA
Prolonged infusion (PI) of β-lactam antibiotics is increasingly used in order to optimise antibiotic exposure in critically ill patients. Physicians are often not aware of a number of subtleties that may jeopardise the treatment. In this clinically based paper, we stress pragmatic issues, such as the importance of a loading dose before PI, and discuss a number of important practicalities that are mandatory to benefit from the pharmacokinetic advantages of prolonged β-lactam antibiotic administration.
PMID: 25749200 [PubMed - as supplied by publisher]