Tigecycline exhibits inhibitory activity against Clostridium difficile in the intestinal tract of hospitalised patients.
Int J Antimicrob Agents. 2015 Jan 13;
Authors: Kundrapu S, Hurless K, Sunkesula VC, Tomas M, Donskey CJ
Abstract
No new acquisition of Clostridium difficile occurred among 12 hospitalised patients receiving tigecycline, and pre-existing colonisation was reduced to undetectable levels in 2 patients. Moreover, 91% of stool suspensions obtained during tigecycline therapy exhibited inhibitory activity against C. difficile. These results suggest that tigecycline achieves sufficient concentrations to inhibit intestinal colonisation by C. difficile.
PMID: 25623897 [PubMed - as supplied by publisher]