Tigecycline exhibits inhibitory activity against Clostridium difficile in the intestinal tract of hospitalised patients.

Link to article at PubMed

Tigecycline exhibits inhibitory activity against Clostridium difficile in the intestinal tract of hospitalised patients.

Int J Antimicrob Agents. 2015 Jan 13;

Authors: Kundrapu S, Hurless K, Sunkesula VC, Tomas M, Donskey CJ

Abstract
No new acquisition of Clostridium difficile occurred among 12 hospitalised patients receiving tigecycline, and pre-existing colonisation was reduced to undetectable levels in 2 patients. Moreover, 91% of stool suspensions obtained during tigecycline therapy exhibited inhibitory activity against C. difficile. These results suggest that tigecycline achieves sufficient concentrations to inhibit intestinal colonisation by C. difficile.

PMID: 25623897 [PubMed - as supplied by publisher]

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