Colchicine: Old and New.
Am J Med. 2014 Dec 29;
Authors: Slobodnick A, Shah B, Pillinger MH, Krasnokutsky S
Although colchicine has been a focus of research, debate and controversy for thousands of years, it was only approved by the United States Food and Drug Administration in 2009. Over the past decade, advances in the knowledge of colchicine pharmacology, drug safety and mechanisms of action have led to changes in colchicine dosing and to potential new uses for this very old drug. In this review, we discuss the pharmacologic properties of colchicine and summarize what is currently known about its mechanisms of action. We then discuss and update the use of colchicine in a variety of illnesses, including rheumatic and, most recently cardiovascular diseases.
PMID: 25554368 [PubMed - as supplied by publisher]