Fidaxomicin Therapy in Critically Ill Patients with Clostridium difficile Infection.
Antimicrob Agents Chemother. 2014 Dec 22;
Authors: Penziner S, Dubrovskaya Y, Press R, Safdar A
Fidaxomicin was given to treat proven Clostridium difficile infection (CDI) in 20 patients receiving care in critical care units (CCUs) and compared with 30 patients on general medical floors. At baseline, CCU patients had more initial CDI episodes, severe and complicated disease, and concurrent broad-spectrum antibiotic coverage. On multivariate analysis, response of fidaxomicin therapy among critically ill patients was comparable to that among patients in the general medical wards.
PMID: 25534722 [PubMed - as supplied by publisher]