The Potential Role of Natriuretic Peptide Guided Management for Patients Hospitalized for Heart Failure.
J Card Fail. 2014 Nov 26;
Authors: Maisel A, Xue Y, Greene SJ, Pang PS, Januzzi JL, Piña IL, DeFilippi C, Butler J
There are over 1 million hospitalizations for heart failure (HF) in the United States annually. Despite contemporary therapy, following discharge, 25% of these patients are rehospitalized within 30 days and 30% are dead within 1 year. To date, all trials in patients with acute HF (AHF) have failed to improve post-discharge outcomes. There remains a need for an effective objective risk stratification strategy that is capable of reliably identifying patients at heightened risk for readmission and informing discharge decision-making. Natriuretic peptides (NP) levels during and after AHF hospitalization can provide valuable information regarding congestion status and chronic remodeling stress. The lack of sensitivity and inter-rater reliability of physical examination and failure to achieve dry weight in many patients prior to discharge renders the use of NP to guide therapy to prevent readmission an attractive option. NP levels can be used across the spectrum of AHF care settings, ranging from the emergency department, inpatient stay, post discharge follow-up, and chronic management. This review summarizes available data and provides an expert opinion on the potential role of NPs to reduce HF readmissions.
PMID: 25433362 [PubMed - as supplied by publisher]