Limited long-term survival after in-hospital intestinal failure requiring total parenteral nutrition.
Am J Clin Nutr. 2014 Oct;100(4):1102-7
Authors: Oterdoom LH, Ten Dam SM, de Groot SD, Arjaans W, van Bodegraven AA
BACKGROUND: Total parenteral nutrition (TPN) is an invasive and advanced rescue feeding technique that has acceptable short-term survival although at costs of substantial risks. Survival after the clinical use of TPN >6 mo is unknown.
OBJECTIVE: We determined long-term survival after clinical TPN use in a consecutive cohort who were attending an academic hospital.
DESIGN: The study included a prospective cohort with a retrospective analysis of all 537 consecutive episodes of TPN in 437 patients between January 2010 and April 2012. Follow-up was until October 2013 with a total follow-up of 608 patient-years. Survival was analyzed by using Kaplan-Meier and Cox regression.
RESULTS: Survival was 58% in 437 patients with a first-time use of TPN at an average of 1.5 y after the initiation of TPN. The mortality rate was 30 deaths/100 patient-years. Older age, admission at an intensive care unit or a nonsurgical department, lower body mass index, and an underlying malignancy were positively associated with mortality.
CONCLUSION: TPN use, if correctly indicated, is a clinical sign of intestinal failure and a surrogate marker for markedly increased risk of mortality even >1.5 y after TPN use. This trial was registered at clinicaltrials.gov as NCT02189993 with protocol identification name TPN-01.
PMID: 25240075 [PubMed - indexed for MEDLINE]