Pulmonary Effects of IV Injection of Crushed Oral Tablets: "Excipient Lung Disease"

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Pulmonary Effects of IV Injection of Crushed Oral Tablets: "Excipient Lung Disease"

AJR Am J Roentgenol. 2014 Nov;203(5):W506-W515

Authors: Nguyen VT, Chan ES, Chou SH, Godwin JD, Fligner CL, Schmidt RA, Pipavath SN

Abstract
OBJECTIVE. When crushed oral tablets are injected IV, their filler material (excipient) can induce a potentially fatal foreign-body reaction in pulmonary arterioles, presenting as dyspnea and pulmonary hypertension with centrilobular nodules on CT. We will describe the imaging and pathologic features of "excipient lung disease." CONCLUSION. The radiologist has a critical role in recognizing and reporting excipient lung disease because the referring clinician may be unaware of the patient's IV drug abuse.

PMID: 25341165 [PubMed - as supplied by publisher]

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