The Association of Direct Thrombin Inhibitor Anticoagulants with Cardiac Thromboses.
Chest. 2014 Sep 25;
Authors: Davidson BL
Direct thrombin inhibitor (anti-factor IIa) anticoagulants, now established for treatment and prevention of cardiac and venous thromboembolism, have been repeatedly associated with a significantly increased frequency of thrombosis on abnormal cardiac endothelium when compared head-to-head with indirectly-acting therapeutic anticoagulants in studies of sufficient patient number and duration. Although there is uncertainty as to mechanism, the weight of evidence as a class effect warrants prescribing effective anticoagulants other than direct thrombin inhibitors.
PMID: 25254608 [PubMed - as supplied by publisher]