Validation of a model to predict the risk of nephrotoxicity in patients receiving colistin.
Antimicrob Agents Chemother. 2014 Aug 18;
Authors: Phe K, Johnson ML, Palmer HR, Tam VH
Despite concerns of nephrotoxicity, colistin often remains the only effective agent for multidrug-resistant gram-negative infections. Published studies have reported a wide range of nephrotoxicity risk factors. To assess the clinical utility of various models, we compared their performance in predicting risk of nephrotoxicity. We identified a model demonstrating reasonable overall risk assessment with observed/expected ratio of 1.29 (95% CI, 0.68-1.90) and positive predictive value of 87.5% for identifying patients at high risk of developing nephrotoxicity.
PMID: 25136012 [PubMed - as supplied by publisher]