Failure of High-Dose Daptomycin for Bacteremia Caused by Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions.
Clin Infect Dis. 2014 Aug 8;
Authors: Munita JM, Mishra NN, Alvarez D, Tran TT, Diaz L, Panesso D, Reyes J, Murray BE, Adachi JA, Bayer AS, Arias CA
A neutropenic patient with bloodstream infection caused by a daptomycin (DAP)-susceptible Enterococcus faecium (MIC 3 µg/mL) harboring genetic changes associated with DAP-resistance failed high-dose DAP therapy, with persistent bacteremia and selection of additional resistances. DAP monotherapy should be used cautiously against DAP-susceptible E. faecium strains with MICs>2 µg/mL.
PMID: 25107294 [PubMed - as supplied by publisher]