Factors that predict thrombosis in relatives of patients with venous thromboembolism.
Blood. 2014 Jul 21;
Authors: Couturaud F, Leroyer C, Tromeur C, Julian JA, Kahn SR, Ginsberg JS, Wells PS, Douketis JD, Mottier D, Kearon C
Abstract
When counselling first-degree relatives of patients with venous thromboembolism (VTE), it is important to know if factors other than thrombophilia influence their risk of thrombosis. We assessed the risk of VTE in 915 first-degree relatives of patients with provoked VTE, compared this to the risk in 1752 first-degree relatives of patients with unprovoked VTE, and then combined data from the two groups of relatives to identify predictors of thrombosis. There had been 123 VTE in the 2617 first-degree relatives (0.12 per 100 person-years). The risk of VTE in first-degree relatives was higher if the index cases had an unprovoked compared with a provoked VTE (odds ratio [OR] 2.38; 95%CI, 1.43-3.85), if the index case was younger (OR 0.97 per year older; 95%CI, 0.96-0.99) and if an additional family member had VTE (OR 2.71; 95%CI, 2.22-3.31). Among first-degree relatives of an index case with factor V Leiden or the prothrombin 20210A gene variant, the presence of these abnormalities also predicted thrombosis (OR 4.42; 95%CI, 1.35-14.38). We conclude that thrombosis at a young age and unprovoked VTE predicts VTE in first-degree relatives, and that the influence of these two factors is additive.
PMID: 25049279 [PubMed - as supplied by publisher]