Should diabetic ketosis without acidosis be included in ketosis-prone type 2 diabetes mellitus?

Link to article at PubMed

Related Articles

Should diabetic ketosis without acidosis be included in ketosis-prone type 2 diabetes mellitus?

Diabetes Metab Res Rev. 2014 Jan;30(1):54-9

Authors: Xie XJ, Hu Y, Cheng C, Feng TT, He K, Mao XM

Abstract
BACKGROUND: The incidence of ketosis-prone type 2 diabetes is very low except for people of sub-Saharan African origin and African Americans. However, there also are some type 2 diabetes patients with diabetic ketosis without acidosis (DKWA). We question whether DKWA should be included as a subtype of ketosis-prone type 2 diabetes mellitus and compared the clinical characteristics of DKWA and diabetic ketoacidosis (DKA) patients.
METHODS: The study population consisted of 594 consecutive unrelated Chinese inpatients with newly diagnosed type 2 diabetes. Demographic and clinical characteristics (age, gender, family history of diabetes, body mass index, blood pressure and plasma lipid parameters) were recorded. The patients were divided into ketosis-resistant diabetes (KRD), DKWA and DKA groups on the basis of urinary ketones, blood pH and bicarbonate levels. The blood glucose and c-peptide levels of the patients were also evaluated.
RESULTS: The prevalence of KRD, DKWA and DKA were 78.33%, 19.72% and 1.95%, respectively, in the study population. The clinical characteristics of patients with DKWA group patients were similar to those with DKA, except that DKA patients had higher blood glucose and deteriorated β cell function.
CONCLUSIONS: Diabetic ketosis without acidosis and DKA patients share similar clinical characteristics; DKWA should be considered ketosis-prone type 2 diabetes. Therefore, the prevalence of ketosis-prone type 2 diabetes might be underestimated.

PMID: 24038858 [PubMed - indexed for MEDLINE]

Leave a Reply

Your email address will not be published. Required fields are marked *