In-Hospital and 12-Month Outcomes After Acute Coronary Syndrome Treatment in Patients Aged

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In-Hospital and 12-Month Outcomes After Acute Coronary Syndrome Treatment in Patients Aged <40 Years of Age (from the Polish Registry of Acute Coronary Syndromes).

Am J Cardiol. 2014 May 2;

Authors: Trzeciak P, Gierlotka M, Gąsior M, Osadnik T, Hawranek M, Lekston A, Zembala M, Poloński L

Abstract
We aimed to compare the characteristics and in-hospital and 12-month outcomes in patients aged >40 and <40 years with acute coronary syndrome. The analysis involved 789 patients aged <40 years and 63,057 patients aged ≥40 years enrolled in the ongoing Polish Registry of Acute Coronary Syndromes from October 2003 to December 2009. Patients aged <40 years with acute coronary syndrome differed from older patients in their clinical characteristics, treatment, and clinical outcome. The older patients more frequently had pulmonary edema (2.9% vs 0.4%, p <0.0001) and cardiogenic shock (4.7% vs 2.8%, p = 0.011) on admission. For the younger patients, coronary angiography and percutaneous coronary intervention were performed more often (71.5% vs 60.5%, p <0.0001 and 51.5% vs 47.7%, p = 0.04, respectively). The younger patients had a lower mortality rate than the older patients during hospitalization (1.5% vs 5.2%, p <0.0001) and during 12-month follow-up period (4.1% vs 13.4%, p <0.0001). Multivariate analysis revealed that age <40 years was one of the strongest factors associated with lower mortality during the 12 months after discharge (hazard ratio 0.42, 95% confidence interval 0.29 to 0.62, p <0.0001). In conclusion, younger patients had more favorable in-hospital and 1-year outcomes than older patients, and the age <40 years was revealed to be one of the strongest factors associated with lower mortality during the 1-year follow-up.

PMID: 24878122 [PubMed - as supplied by publisher]

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