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Prognosis and treatment in patients admitted with acute myocardial infarction on weekends and weekdays from 1997 to 2009.
Int J Cardiol. 2013 Sep 30;168(2):1167-73
Authors: Hansen KW, Hvelplund A, Abildstrøm SZ, Prescott E, Madsen M, Madsen JK, Jensen JS, Sørensen R, Galatius S
Abstract
BACKGROUND: Less invasive treatment and poorer outcomes have been shown among patients admitted with acute myocardial infarction (AMI) on weekends compared to weekdays.
OBJECTIVES: To investigate the 'weekend-effect' on mortality in patients with AMI.
METHODS: Using nationwide registers we identified 92,164 patients aged 30-90 years who were admitted to a Danish hospital with a first AMI from 1997 to 2009. Patients were stratified according to weekday- or weekend admissions and four time-periods to investigate for temporal changes. All-cause mortality at 2, 7, 30, and 365 days was investigated using proportional hazards Cox regression.
RESULTS: Mortality rates were higher on weekends within seven days of admission in 1997-99 (absolute difference ranging from 0.8 to 1.1%). Weekend-weekday hazard-ratios were 1.13 (1.03-1.23) at day 2 and 1.10 (1.01-1.18) at day 7. There were no significant differences in 2000-09 and estimates suggested an attenuation of the initial 'weekend-effect'. Overall, the use of coronary angiography (34.9% vs. 72.3%) and percutaneous coronary intervention (6.6% vs. 51.0%) within 30 days increased, as did the use of statins (49.9% vs. 80.1%.) and clopidogrel (26.7% vs. 72.7%). The cumulative mortality decreased during the study period from 5.4% to 2.5% at day of admission, from 19.5% to 11.0% at day 30 and from 28.0% to 19.0% at day 365 (all tests for trend p<0.0001).
CONCLUSIONS: No persistent 'weekend-effect' on mortality was present in patients with AMI in 1997-2009. Overall, mortality rates have decreased concomitantly with an increased use of current guideline-recommended invasive and medical therapy.
PMID: 23199552 [PubMed - indexed for MEDLINE]