A cost-analysis model for anticoagulant treatment in the hospital setting.
J Med Econ. 2014 Apr 28;
Authors: Mody SH, Huynh L, Zhuo DY, Tran KN, Lefebvre P, Bookhart B
Abstract Background: Rivaroxaban is the first oral factor Xa inhibitor approved in the US to reduce the risk of stroke and blood clots among people with non-valvular atrial fibrillation, treat deep vein thrombosis (DVT), treat pulmonary embolism (PE), reduce the risk of recurrence of DVT and PE, and prevent DVT and PE after knee or hip replacement surgery. The objective of this study was to evaluate the costs from a hospital perspective of treating patients with rivaroxaban versus other anticoagulant agents across these five populations. Methods: An economic model was developed using treatment regimens from the ROCKET-AF, EINSTEIN-DVT and PE, and RECORD1-3 randomized clinical trials. The distribution of hospital admissions used in the model across the different populations was derived from the 2010 Healthcare Cost and Utilization Project database. The model compared total costs of anticoagulant treatment, monitoring, inpatient stay, and administration for patients receiving rivaroxaban versus other anticoagulant agents. The length of inpatient stay (LOS) was determined from the literature. Results: Across all populations, rivaroxaban was associated with an overall mean cost savings of $1,520 per patient. The largest cost savings associated with rivaroxaban was observed in patients with DVT or PE ($6,205 and $2,742 per patient, respectively). The main driver of the cost savings resulted from the reduction in LOS associated with rivaroxaban, contributing to approximately 90% of the total savings. Furthermore, the overall mean anticoagulant treatment cost was lower for rivaroxaban versus the reference groups. Limitations: The distribution of patients across indications used in the model may not be generalizable to all hospitals, where practice patterns may vary, and average LOS cost may not reflect the actual reimbursements that hospitals received. Conclusion: From a hospital perspective, the use of rivaroxaban may be associated with cost savings when compared to other anticoagulant treatments due to lower drug cost and shorten LOS associated with rivaroxaban.
PMID: 24773068 [PubMed - as supplied by publisher]