Predominance of Gram-negative bacilli among patients with catheter-related bloodstream infections.
Clin Microbiol Infect. 2014 Jan 24;
Authors: Braun E, Hussein K, Geffen Y, Rabino G, Bar-Lavie Y, Paul M
We evaluated changes in the epidemiology of catheter-related bloodstream infections (CRBSIs) between 1996-2012 in a tertiary care center in Israel. The cohort included 1,754 episodes of CRBSI. The incidence of CRBSIs decreased throughout the study period, while 30-day mortality following bacteremia increased. There was a linear shift toward predominance of Gram-negative bacilli throughout the study period (p for trend<0.001). In 1996, 68% (68/100) CRBSIs were caused by Gram-positive cocci, while in 2012 77.8% (28/26) were caused by Gram-negative bacilli. The shift towards Gram-negative CRBSIs and the associated mortality mandates that empirical treatment for CRBSIs be directed by local epidemiology. This article is protected by copyright. All rights reserved.
PMID: 24461043 [PubMed - as supplied by publisher]