Statin Use and Clinical Outcomes among Pneumonia Patients.
Clin Microbiol Infect. 2014 Jan 23;
Authors: Chung SD, Tsai MC, Lin HC, Kang JH
It was suggested that statin may improve outcomes of pneumonia patients. However, there are sparse data regarding this topic in ethnic Chinese populations. In the present study, we investigated associations between prior statin use and pneumonia outcomes in Taiwan with a large-scale matched cohort study. Totally 11,576 patients with pneumonia were selected consisting of 2894 patients with prior statin use and 8682 matched patients. We used a separate conditional logistic regression to explore relationships between statin use and each clinical outcome, including 'ICU admission,' 'use of mechanical ventilation,' 'acute respiratory failure,' and 'in-hospital death.' We found that patients who were statin users were 0.81- (95% confidence interval (CI): 0.74~0.89), 0.80- (95% CI: 0.71~0.89), 0.84- (95% CI: 0.75~0.94), and 0.69-times (95% CI: 0.57~0.85) less likely to be admitted to the ICU, to have acute respiratory failure, to need mechanical ventilation, and to die in the hospital, respectively, than patients who were not statin users. In addition, it consistently revealed that compared to patients who were not statin users, regular statin users had lower ORs of ICU admission, acute respiratory failure, the use of mechanical ventilation, and in-hospital death. However, there were no significant differences in the above adverse outcomes between irregular statin users and non-statin users. We concluded that patients with regular prior statin use were significantly associated with favorable outcomes during admission for pneumonia in Taiwan. This article is protected by copyright. All rights reserved.
PMID: 24450510 [PubMed - as supplied by publisher]