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Do Pharmacogenetics Have a Role in the Dosing of Vitamin K Antagonists?
N Engl J Med. 2013 Nov 19;
Authors: Furie B
Abstract
Vitamin K plays a single role in human biology - as a cofactor for the synthesis of γ-carboxyglutamic acid. This amino acid is a component of at least 14 proteins, including 4 blood-coagulation proteins (factor IX, factor VII, factor X, and prothrombin) and 2 regulatory proteins (protein C and protein S), and it is critical for the physiologic function of these proteins. Humans do not synthesize vitamin K. Rather, we ingest it in our diet. The vitamin K quinone is reduced to the semiquinone, and this reduced vitamin K is a cofactor that is required for the conversion of specific . . .
PMID: 24251364 [PubMed - as supplied by publisher]