Impact of toxigenic Clostridium difficile polymerase chain reaction testing on the clinical microbiology laboratory and inpatient epidemiology.
Diagn Microbiol Infect Dis. 2013 Aug;76(4):534-8
Authors: Napierala M, Munson E, Skonieczny P, Rodriguez S, Riederer N, Land G, Luzinski M, Block D, Hryciuk JE
Conversion from Clostridium difficile toxin A/B EIA to tcdB polymerase chain reaction for diagnosis of C. difficile infection (CDI) resulted in significant decreases in laboratory testing volume and largely unchanged C. difficile toxin detection rates. Decreases in healthcare-associated CDI rates (P ≤ 0.05) reflected a clinical practice benefit of this conversion.
PMID: 23731555 [PubMed - indexed for MEDLINE]