Daptomycin Activity when Tested against Uncommonly Isolated Streptococcal and Other Gram-positive Species Groups.
Antimicrob Agents Chemother. 2013 Sep 30;
Authors: Sader HS, Flamm RK, Farrell DJ, Jones RN
Abstract
1,356 clinical isolates were tested against daptomycin by broth microdilution methods. Daptomycin was active against seven groups of viridans group streptococci (MIC50/90 ranging from ≤0.06/≤0.06 μg/mL [Streptococcus bovis and S. dysgalactiae] to 0.5/1 μg/mL [S. mitis, S. oralis and S. parasanguinis]), β-hemolytic streptococci serogroups C, F and G (MIC50/90, ≤0.06-0.25/0.12-0.25 μg/mL), Corynebacterium spp. (MIC50/90, ≤0.06/0.12 μg/mL) and Micrococcus spp. (MIC50/90, ≤0.06/0.25 μg/mL). Listeria monocytogenes exhibited higher daptomycin MICs (MIC50/90, 2/4 μg/mL).
PMID: 24080651 [PubMed - as supplied by publisher]