Daptomycin Activity when Tested against Uncommonly Isolated Streptococcal and Other Gram-positive Species Groups.
Antimicrob Agents Chemother. 2013 Sep 30;
Authors: Sader HS, Flamm RK, Farrell DJ, Jones RN
1,356 clinical isolates were tested against daptomycin by broth microdilution methods. Daptomycin was active against seven groups of viridans group streptococci (MIC50/90 ranging from ≤0.06/≤0.06 μg/mL [Streptococcus bovis and S. dysgalactiae] to 0.5/1 μg/mL [S. mitis, S. oralis and S. parasanguinis]), β-hemolytic streptococci serogroups C, F and G (MIC50/90, ≤0.06-0.25/0.12-0.25 μg/mL), Corynebacterium spp. (MIC50/90, ≤0.06/0.12 μg/mL) and Micrococcus spp. (MIC50/90, ≤0.06/0.25 μg/mL). Listeria monocytogenes exhibited higher daptomycin MICs (MIC50/90, 2/4 μg/mL).
PMID: 24080651 [PubMed - as supplied by publisher]