Emergence of community-acquired Adenovirus Type 55 as a cause of community-onset pneumonia.

Link to article at PubMed

Emergence of community-acquired Adenovirus Type 55 as a cause of community-onset pneumonia.

Chest. 2013 Sep 26;

Authors: Cao B, Huang GH, Pu ZH, Qu JX, Yu XM, Zhu Z, Dong JP, Gao Y, Zhang YX, Li XH, Liu JH, Wang H, Xu Q, Li H, Xu W, Wang C

ABSTRACT BACKGROUND From 2008, sporadic cases of severe cases caused by emerging Human Adenovirus Type 55 (HAdV-55) were reported in China. But no comparative studies have been conducted to discern the differences in epidemiological and clinical abnormalities between HAdV-55 and other types (HAdV-7, 3, 14, 50 and C). METHODS A multi-center surveillance study for adult and adolescent community-acquired pneumonia was conducted prospectively in Beijing and Yan Tai between November 2010 and April 2012. A standardized data form was used to record clinical information. The viral DNA extracted from the clinical samples or adenovirus viral isolates were sequenced.
RESULTS: Among 969 cases, 48 (5%) were identified as adenovirus pneumonia. Six branches were clustered: HAdV-55 in 21; HAdV-7 in 11; HAdV-3 in 9; HAdV-14 in 4; HAdV-50 in 2 and HAdV-C in 1. Most HAdV-55 was identified during February and March. All the hypervariable region of the hexon genes of the 21 HAdV-55 strains was completely identical. Compared with other types (HAdV-7, 3, 14, 50 and C), patients due to HAdV-55 were about 10 years older (p=0.027) and had higher PSI score (p=0.030). Systemic blood pressure was also higher among patients in HAdV-55 group (p=0.006). Unilateral or bilateral consolidations were the most common radiological findings in both HAdV-55 group and other types (57.9% vs 36%). More than half of the patients were admitted to hospitals, oxygen therapy was given to 29.2% of the patients and two of them needed mechanical ventilation. CONCLUSIONS HAdV-55 has established itself as a major pneumonia pathogen among Chinese population and further surveillance and monitoring of this agent as a cause of CAP is warranted.

PMID: 24077315 [PubMed - as supplied by publisher]

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