Long-acting bronchodilators improve Health Related Quality of Life in patients with COPD.

Link to article at PubMed

Long-acting bronchodilators improve Health Related Quality of Life in patients with COPD.

Respir Med. 2013 Aug 31;

Authors: Braido F, Baiardini I, Cazzola M, Brusselle G, Marugo F, Canonica GW

Abstract
BACKGROUND: Long-acting bronchodilators are first-line treatment for chronic obstructive pulmonary disease (COPD), and their efficacy on lung function and clinical parameters is recognized.
OBJECTIVE: To explore the available evidence about the effects of long acting bronchodilators on Health Related Quality of Life (HRQoL) and Health Status (HS) in clinical research.
METHODS: Randomized controlled trials published till December 2012 evaluating HRQoL/HS in COPD by means of validated questionnaires were analysed.
RESULTS: Fifty-one trials on Long acting β2 agonist (LABA) and Long acting Anticholinergic (LAMA) met the inclusion criteria. A total of 37,225 moderate-severe COPD patients testing 6 drugs, 12 different devices and 22 different dosages, with a study duration ranging from 4 weeks to 4 years were studied. A statistical significant HRQoL/HS improvement was reached in 93% of the studies. Nevertheless, the Minimal Important Difference (MID) was reached in 70,6% of the studies considering the difference between baseline and end of the study, and in 50% when comparing active treatment and placebo.
CONCLUSIONS: The data coming from the review support the efficacy of long acting bronchodilators in improving HRQoL/HS of COPD patients. Further research evaluating HRQoL/HS as primary outcome and according to guidelines on Patient Reported Outcomes is needed.

PMID: 24001507 [PubMed - as supplied by publisher]

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