Association of liver cirrhosis with group B Streptococcal bacteremia in non-pregnant adults.

Link to article at PubMed

Association of liver cirrhosis with group B Streptococcal bacteremia in non-pregnant adults.

J Infect. 2013 Aug 30;

Authors: Cho SY, Kang CI, Kim J, Joo EJ, Ha YE, Chung DR, Lee NY, Peck KR, Song JH

Abstract
OBJECTIVES: Older age and underlying medical conditions have been reported as predisposing risk factors for Group B Streptococcus (GBS) infection. However, less is known about the specific association of liver cirrhosis (LC) with GBS bacteremia.
METHODS: A retrospective, matched case-control study (1:2 ratio) was conducted. Adult patients with GBS bacteremia from January 2000 through April 2012 were included in the case group. Control group consisted of patients with bacteremia by organism other than GBS.
RESULTS: A total of 342 patients were included in this study (114 cases and 228 controls). Malignancy (57.0%), diabetes (29.1%) and LC (27.4%) were common underlying diseases in patients with GBS bacteremia. The common site of infection among GBS bacteremia was skin and soft tissue infection (24.8%) and primary bacteremia (21.4%). LC (P=0.007), skin and soft tissue infection (P<0.001), primary bacterermia (P=0.023) were more common in patients with GBS bacteremia than in the controls. In the multivariate analysis, LC was significantly associated with the development of GBS bacteremia (OR, 2.04; 95% CI, 1.14-3.68; P = 0.017).
CONCLUSIONS: In this case-control study, LC was identified as an independent risk factor for GBS bacteremia. GBS should be considered an important cause of infection in patients with LC.

PMID: 23999150 [PubMed - as supplied by publisher]

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