The Randomized Registry Trial - The Next Disruptive Technology in Clinical Research?
N Engl J Med. 2013 Aug 31;
Authors: Lauer MS, D'Agostino RB
Abstract
The randomized trial is one of the most powerful tools clinical researchers possess, a tool that enables them to evaluate the effectiveness of new (or established) therapies while accounting for the effects of unmeasured confounders and selection bias by indication. Randomized trials, especially huge megatrials, have transformed medical practice. Thanks to randomized trials, we no longer, for example, treat acute myocardial infarction with lidocaine and nitrates. Instead we use rapid revascularization, anticoagulants, and antiplatelet agents, and during long-term follow-up we routinely prescribe statins, beta-blockers, and angiotensin-converting-enzyme inhibitors. But the reputation of randomized trials has suffered of late,(1) owing to reasonable . . .
PMID: 23991657 [PubMed - as supplied by publisher]